SPACE is a variant of the three-dimensional (3D) turbo spin echo sequence. Compared to a conventional turbo spin echo sequence, SPACE uses non-selective, short refocusing pulse trains consisting of RF pulses with variable flip angles. This allows for achieving very high turbo factors (> 100) and high sampling efficiency. The SPACE sequence produces high-resolution isotropic images that can be reconstructed in multiple planes. SPACE sequences are less sensitive to susceptibility, flow, and chemical shift artifacts, which makes them superior to conventional turbo spin echo sequences. By utilizing a SPACE sequence, it is possible to generate isotropic 0.9mm 3D TIR, FLAIR, and T2 contrast images in less than 7 minutes.